Out of downtown Napa, over Jameson Canyon and up I-80 to Auburn, then the long way in: Foresthill, Mosquito Ridge, French Meadows and Hell Hole Road.
Out of downtown Napa and up I-80 to Auburn, then Georgetown Road and Wentworth Springs Road deep into El Dorado County, past Quintette and on toward Uncle Tom's Cabin.
Out of downtown Napa through Jameson Canyon and across the Delta by Rio Vista and Walnut Grove, then Highway 50 all the way up past Placerville, Kyburz and Strawberry to Echo Summit.
Out of downtown Napa on I-80 all the way over to Truckee, then down the west shore of Lake Tahoe to the Rubicon Trail and past Emerald Bay.
Out of downtown Napa on Highway 12 across the Delta to Stockton, then CA-4 and Highway 108 up past Mi-Wuk Village and over Sonora Pass, the highest road on this list.
Day one: out of downtown Napa on Highway 12 across the Delta, then CA-88 up through Pioneer and Kirkwood and over Carson Pass, down past Woodfords to US 395 and south through Topaz to Walker for the night.
Out of downtown Napa on I-80, then Highway 50 the whole way up past Pollock Pines, Kyburz and Echo Summit into the Tahoe basin.
Out of downtown Napa on Highway 12 through Fairfield and Rio Vista to Stockton, then down through Chinese Camp and up Highway 108 past Cold Springs and Dardanelle to Sonora Pass.
North out of downtown Napa through Calistoga and Geyserville to Cloverdale, then Skaggs Springs Road over the hills to the coast at Sea Ranch and up to Gualala.
Out of downtown Napa through Petaluma and Santa Rosa to Healdsburg, then 128 and Fish Rock Road over the hills to the coast.
Out of downtown Napa over 37 to Petaluma and Point Reyes–Petaluma Road to Point Reyes Station, then Highway 1 down to Stinson Beach and back up through Olema.
North out of downtown Napa through St. Helena to Cloverdale, then 128 through Anderson Valley and Philo to the coast at Albion.
Out of downtown Napa on I-80 to Auburn and up Highway 49 to Nevada City, then North Bloomfield Road, Tyler Foote Crossing and Pliocene Ridge Road through Alleghany and Forest.
Out of downtown Napa on I-80 and Highway 50 to Placerville, then up Union Ridge and Mosquito Road to the bridge the ride is named after.
Out of downtown Napa on I-80 and Highway 50 to Pollock Pines, then north on Ice House Road and over to Wentworth Springs Road past Quintette.
A short one. Out of downtown Napa through American Canyon and Vallejo, over the Cummings Skyway, then Martinez and Highway 24 through Lafayette and Orinda to Skyline Boulevard along the Oakland Hills.